Statins are taken before bedtime because the enzyme responsible for cholesterol synthesis has a circadian rhythm, with the liver’s ability to synthesize cholesterol being strongest at night, peaking around midnight. Therefore, taking statins before sleep is appropriate. However, due to differences in the half-life of the drugs, short-acting lipid-lowering drugs such as simvastatin and lovastatin, both of which have lipophilic lactone ring structures, have their bioavailability increased by food, so taking them at dinner is optimal for better lipid-lowering effects. Pravastatin and fluvastatin possess both lipophilic and hydrophilic properties, and their oral absorption is generally not affected by food, so they are usually recommended to be taken before bedtime. The third-generation statins—rosuvastatin, atorvastatin, and pitavastatin—are long-acting lipid-lowering drugs and do not necessarily have to be taken before sleep.
Want to see the mechanism of action of statins 
Recently, I saw that chitosan can be used to lower blood lipids. Do you know if it is applied clinically?
Due to its positive charge, chitosan can effectively bind negatively charged molecules, including fatty acids, lipids, and bile acids, facilitating the proper excretion of these molecules from the body. Therefore, as claimed, chitosan can significantly reduce cholesterol levels in the blood [4,17,18]
Versatile Use of Chitosan and Hyaluronan in Medicine - PMC