Physiologically, when thyroid hormone levels increase, the negative feedback reduces TSH, leading to decreased secretion of thyroid hormone. However, pathologically, patients produce TSH receptor antibodies from unknown sources, which mimic the action of TSH, causing thyroid hormone levels to remain high. Although negative feedback reduces TSH at this time, TSH receptor antibodies are continuously produced, and thyroid hormone is continuously released, resulting in a persistent hyperthyroid state. #ClinicalExperience/Liu Zhongbao
These TSH receptor antibodies are often generated due to emotions, stress, and other factors.