Excessive Damage to Vascular Endothelium
Origin and Clearance
Source:
- Nucleic acid metabolism (80%): When inflammation, chemotherapy, or tissue damage occurs, cell death increases, releasing more RNA and DNA, leading to increased urea
- Food (20%)
Metabolism:
- Digestive tract (30%)
- Kidney (70%): 100% filtration, 90% reabsorption, 10% excretion. Once kidney function is impaired, a large amount of uric acid accumulates
Treatment
- Febuxostat, Allopurinol — inhibit xanthine oxidase, thereby reducing uric acid production
- Colchicine, Nonsteroidal anti-inflammatory drugs (NSAIDs), Glucocorticoids — inhibit inflammation, thereby reducing nucleotide release caused by cell death
- Benzbromarone, Probenecid — inhibit renal reabsorption
Others
Humans and apes lack uricase, making them prone to high uric acid levels. Other mammals do not, because uricase inhibits the conversion of fructose into triglycerides
Recruiting gout patients (Febuxostat sustained-release) 北京地区招募痛风患者