Teaching video 凝血机制「瀑布学说」华法林与维生素K的关系_哔哩哔哩_bilibili
The coagulation cascade reaction occurs on the surface of the cell membrane. FⅣ is an adhesive used to connect FⅡ, FⅦ, FⅨ, and FⅩ. Their glutamic acid residues have carboxyl groups that can bind calcium ions, allowing them to remain on the cell membrane surface to carry out the coagulation cascade reaction.
Vitamin K is a cofactor of the carboxylase enzyme. Warfarin inhibits the production of reduced vitamin K by inhibiting epoxide reductase, resulting in FⅡ, FⅦ, FⅨ, and FⅩ not being carboxylated and thus unable to reach the cell membrane surface and bind to FⅣ, thereby preventing the reaction on the cell membrane surface.